In aerospace industry, new design concepts which offer weight saving are widely discussed. Advanced lightweight design is often characterized by choosing the right material for the right application. In this connection adhesive bonding is recommended to max out the material and joining properties. Laser treatment is showing promising results to deliver a reliable surface treatment technology to prepare composite and metal surfaces for adhesive bonding. In this study ns-pulsed laser systems are used to remove adhesion-weakening contaminations off composite surfaces and to generate open porous oxide structures on metals. An ultra-violet laser cleaning process, based on 266 nm wavelength, was developed to reduce the exposure of carbon fibres. Scanning electron microscopy (SEM) and x-ray photoelectron spectroscopy (XPS) investigations of different carbon fibre reinforced thermoplastic and thermosets reveal the influence of this laser cleaning process on the chemical composition and the surface morphology. The positive impact of the laser cleaning process on adhesive bonding is shown by an 100 % increase of joint strength compared to the reference process grinding. Single lap shear tests of laser pre-treated Ti6Al4V metal samples, of thermoset and thermoplastic composites as well as of adhesively bonded Ti6Al4V-composite hybrid joints demonstrate the high potential of laser technology for surface preparation before hybrid bonding.